The frequently welcomed 'cheat day' as a common theme in lots of diets and the popular ketogenic diet plan is no exception. Researchers discovered that a 75-gram dose of glucose is equivalent to a large bottle of soda or a plate of fries.

"The ketogenic or keto diet plan has actually become extremely typical for weight loss or to handle illness like type 2 diabetes. It consists of consuming foods abundant in fats, moderate in protein, but very low in carbohydrates and it triggers the body to go into a state called ketosis," stated Jonathan Little, associate professor in the School of Health and Exercise Sciences at UBCO and study senior author of the study released in the journal, 'Nutrients'.

Little said the diet can be very reliable due to the fact that once the body remains in ketosis and starved for its preferred fuel glucose, the body's chemistry modifications and it starts to aggressively burn its fat shops. This causes weight loss and can reverse the signs of diseases like Type 2 diabetes.

"We were interested in discovering out what takes place to the body's physiology when a dose of glucose is reestablished. Considering that impaired glucose tolerance and spikes in blood sugar levels are understood to be connected with an increased risk in cardiovascular disease, it made sense to take a look at what was happening in the capillary after a sugar hit," said Cody Durrer, UBC Okanagan doctoral student and study the first author.

For their test, the scientists hired 9 healthy young males and had them take in a 75-gram glucose beverage prior to and after a seven-day high fat, low carbohydrate diet plan. The diet consisted of 70 per cent fat, 10 per cent carbohydrates, and 20 per cent protein, similar to that of a modern ketogenic diet.

"We were originally trying to find things like an inflammatory reaction or minimized tolerance to blood sugar. What we found rather were biomarkers in the blood recommending that vessel walls were being harmed Alka Tone Keto by the sudden spike in glucose," stated Durrer.

Little said the most likely perpetrator for the damage is the body's own metabolic response to excess blood sugar level, which causes capillary cells to shed and potentially die.

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"Even though these were otherwise healthy young males when we looked at their capillary health after consuming the glucose drink, the outcomes looked like they may have come from somebody with poor cardiovascular health. It was somewhat alarming," added Little.

The scientists pointed out that with only nine people consisted of in the study, more work is required to validate their findings, however that the results should provide those on a keto diet time out when thinking about a cheat day.

"My concern is that much of individuals going on a keto diet plan-- whether it's to lose weight, to treat Type 2 diabetes, or some other health reason-- may be undoing some of the positive influence on their blood vessels if they all of a sudden blast them with glucose. Particularly if these individuals are at a higher threat for heart disease in the first place," he said.